DISEASE MOUSE MODELS

Model animals, as an important tool for human disease research, aid in the investigation of disease mechanisms and the development of therapies. Mouse models, being the most extensively used model animals, are employed in a variety of areas, such as fundamental scientific research, drug discovery, preclinical evaluation, and clinical technology development. Mice have a close relationship with humans, advanced genetic manipulation, fast reproduction, and a clear genetic background. Gene editing technology can provide suitable disease models for study based on disease-related genes. GemPharmatech has produced numerous disease models using gene editing technologies, such as spontaneous tumor models, obesity models, diabetes models, Alzheimer's disease models, Parkinson's disease models, and so on. Through phenotypic analysis, GemPharmatech has also confirmed the incidence and development of numerous model-related phenotypes, providing solid support for the research of various diseases.

Introducing GemPharmatech's Latest Strains: Unveiling the Future of Innovation


Strain ID

Strain Name

Application

T055223


B6-Tg(hSOD1 G93A,hSOD1) 图片1.png

Genetic humanization, ALS disease

T058996

FAD4T-hTREM2 图片1.png

Genetic humanization, Alzheimer's disease

T054322

B6-hSNCA E46K A53T

Genetic humanization, Parkinson's disease

T056757

B6-hCD36

Genetic humanization, neuroinflammation

T056002

B6-Dmd Del45

Duchenne muscular dystrophy, 45 exon deletion

T055631

B6-hDLL4

Genetic humanization, oncology

T056429

B6-hCD34

Genetic humanization, oncology

T058753

B6-hCEACAM5-Tg

Genetic humanization, oncology

T053316

B6-hIL18R1/hIL18RAP

Genetic humanization, oncology

T037007

B6-hCD47/hSIRPA 图片1.png

Genetic humanization, oncology

T056010

BALB/c-hCD44

Genetic humanization, oncology

T054198

BALB/c-hGPC3

Genetic humanization, oncology

T054490

BALB/c-hSEMA4D

Genetic humanization, oncology

T054543

BALB/c-hHSA

Genetic humanization, oncology

T056432

BALB/c-hTROP2 图片1.png

Genetic humanization, oncology

T056011

BALB/c-hCD44v6

Genetic humanization, oncology

T055714

BALB/c-hCS1

Genetic humanization, oncology

T056083

BALB/c-hLRRC15

Genetic humanization, oncology

T056430

BALB/c-hNECTIN-4

Genetic humanization, oncology

T058266

BALB/c-hTIGIT/hPVRIG

Genetic humanization, oncology

T054842

BALB/c-hPD1/hPDL1/hTIGIT/hCD9 图片1.png

Genetic humanization, oncology

T058749

BALB/c-hPD1/hPDL1/hCD73/hCD39 图片1.png

Genetic humanization, oncology

T009819


BALB/c-hHER2 图片1.png


Genetic humanization, oncology

T009813

NCG-hHER2

Genetic humanization, oncology

T054081

NOD-Scid-hNKp30

Genetic humanization, oncology

T056195

B6-hIGHA1

Genetic humanization, autoimmune disease


T054583

BALB/c-hIL1RL1

Genetic humanization, autoimmune disease

T054645

BALB/c-hKLRB1

Genetic humanization, autoimmune disease

T003277

BALB/c-hIL17A 图片1.png

Genetic humanization, autoimmune disease

T053555

BALB/c-hIL1β

Genetic humanization, autoimmune disease

T054186

BALB/c-hTLR8

Genetic humanization, autoimmune disease

T055268

BALB/c-hFcgRs/hCD47/hSIRPA 图片1.png

Genetic humanization, Fc end modification for antibody drugs, ADCC effect

T058940

BALB/c-hCD3EDG/hCD22

Genetic humanization, CD3 bispecific antibody related

T057420

BALB/c-hCD73/hCD3EDG 

Genetic humanization, CD3 bispecific antibody related

T058817

BALB/c-hGPRC5D/hCD3EDG 图片1.png

Genetic humanization, CD3 bispecific antibody related

T059045

BALB/c-hCD3EDG/hBCMA 图片1.png

Genetic humanization, CD3 bispecific antibody related

T058351

B6-Rosa26-hAGT 图片1.png

Genetic humanization, hypertension

T058352

B6-H11-hREN

Genetic humanization, hypertension

T054639

B6-hCD200R1

Genetic humanization, atherosclerosis research

T058217

B6-hAPOB-Tg

Genetic humanization, hypercholesteremia and atherogenesis

T058211

B6-hAPOE-DGAT2-LE1 图片1.png

Genetic humanization, NASH

T051403

B6-Myh6-R404Q 图片1.png

Hypertrophic cardiomyopathy

T027708

B6-Mybpc3-KO

hypertrophic cardiomyopathy or dilated cardiomyopathy

T007085

B6-Kras-G12D/wt; Lyz2-iCre

Spontaneous lung cancer

T053603

kras-G12C 图片1.png

Kras-related spontaneous tumors

T057165

KPS 图片1.png

Spontaneous lung cancer

T057162

KS

Spontaneous lung cancer


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